|Basic InformationMore InformationTestsLatest News|Depression Inversely Linked to Body Composition in TeensReview: Depression Screening As Inpatient Important, FeasibleDepression Can Slow Hospital Patients' Recovery: StudyAntidepressants During Pregnancy Safe for Baby: StudyWhat You Need to Know About AntidepressantsAPA: Internet-Based CBT Can Be Helpful in DepressionCan Online Treatment Replace Your Therapist?Depression Often a Precursor to Falls in Elderly PeopleObesity, Sex Predict Remission for Antidepressant MedicationsGender Differences in Depression Tend to Appear About Age 12Depression's Gender Gap Shows Up in Pre-Teen YearsStudies Question Link Between Mom's Antidepressant Use, Autism in KidsTrauma as a Teen May Boost Depression Risk Around MenopauseBlood Test Promising for ID of Early Depression, SchizophreniaBlood Test Might Someday Distinguish Early Depression, SchizophreniaHold That Pose: Yoga May Ease Tough DepressionDepression May Hasten Death in Years After Heart DiagnosisAntidepressant Efficacy Varies for Depressive Symptom ClustersDepressed Psoriasis Patients at Higher Risk of Psoriatic ArthritisCan Depression Up Odds for Arthritis Linked to Psoriasis?Postpartum Depressive Symptoms Fell in 2004 to 2012Depression Often Untreated in Dialysis PatientsPostpartum Depression Affects New Dads, TooPanic Disorder May Up Odds of Depression Rx Side EffectsSometimes the Holidays Aren't Always JollyPilots Suffer Depression, Suicidal Thoughts at Fairly High RatesMore Than 1 in 10 Pilots Suffer From Depression, Survey FindsSelf-Care Tools Cut Depression in AMD, Diabetic RetinopathyDepression, Suicide Ideation Prevalent in Medical StudentsDepression on the Rise Among U.S. Teens, Especially GirlsDepressive Symptoms Linked to Functional Status in CADHigh Rate of Antidepressant Use After CancerResearchers Find Antidepressant Bupropion Crosses PlacentaMom-to-Be's Antidepressant Use May Be Tied to Speech Issues in ChildDepression Can Fuel Heart Disease in Midlife Women: StudyDepression Common in Patients With Chronic AnginaFacebook Bullying Can Cause DepressionMany Cases of Depression in Adults Not Being TreatedMany Depressed Adults Not Getting Treatment: StudyMajor Depressive Disorder Ups Acute MI Risk in HIV-InfectedPostpartum Depression Can Be ID'd During Infant HospitalizationDepression Common After Time Spent in ICUDepression Can Stalk Families Through GenerationsScientists Spot 15 Regions of Human DNA Linked to DepressionBehavioral Activation Therapy Viable Option in DepressionCould New 'Talk Therapy' Cut Cost of Treating Depression?Baseline Depression Symptoms Tied to Low Med AdherenceDepression Linked to CKD in Patients With DiabetesDiabetic Retinopathy Independently Tied to DepressionDepression Strikes Nearly 3 Million U.S. Teens a YearQuestions and AnswersVideosLinksBook Reviews
Scientists Spot 15 Regions of Human DNA Linked to Depression
by -- Robert Preidt
Updated: Aug 1st 2016
MONDAY, Aug. 1, 2016 (HealthDay News) -- Researchers say they've identified 15 regions of human DNA associated with depression.
These regions may contain genes that increase the risk of depression, said the researchers, although the study does not prove these genes cause depression.
"Identifying genes that affect risk for a disease is a first step towards understanding the disease biology itself, which gives us targets to aim for in developing new treatments," said corresponding study author Dr. Roy Perlis. He's with the Center for Human Genetic Research at Massachusetts General Hospital in Boston.
"More generally, finding genes associated with depression should help make clear that this is a brain disease, which we hope will decrease the stigma still associated with these kinds of illnesses," he said in a hospital news release.
The researchers analyzed data from more than 300,000 people of European ancestry that was collected by the consumer genetic profiling company 23andMe. More than 75,000 of the people in the study had been diagnosed with or treated for depression.
The analysis pinpointed 15 regions of DNA, including 17 specific sites, significantly associated with depression risk. Several of these sites are located in or near genes known to be involved in brain development.
"The neurotransmitter-based models we are currently using to treat depression are more than 40 years old, and we really need new treatment targets. We hope that finding these genes will point us toward novel treatment strategies," said Perlis, who is also an associate professor of psychiatry at Harvard Medical School.
"Another key takeaway from our study is that the traditional way of doing genetic studies is not the only way that works. Using existing large data sets or biobanks may be far more efficient and may be helpful for other psychiatric disorders, such as anxiety disorders, where traditional approaches also have not been successful," Perlis said.
The study was published online Aug. 1 in the journal Nature Genetics.
The U.S. National Institute of Mental Health has more on depression.
This article: Copyright © 2016 HealthDay. All rights reserved.